🧠 EVT in Large Core Infarction

ASPECTS Score vs Infarct Core Volume - Trial Eligibility
6 Landmark RCTs | 2022-2024 | n=1,888
📊 Rectangle = Trial's Eligibility Zone
10
9
8
7
6
5
4
3
2
1
0
ASPECTS
0
25
50
75
100 mL
Infarct Core Volume (mL)
✅
LASTE
ASP 0-5
Core 0-100
❌
TESLA
ASP 2-5
Core 0-100
RESCUE
ASP 3-5
Core 0-100
SELECT2
ASP 3-5
Core 50-100
TENSION
ASP 3-5
Core 70-100
6
Trials
1,888
Patients
5
Positive
1
Negative

📋 Trial Eligibility Details

🟢 RESCUE-JAPAN LIMIT (2022)
ASPECTS 3-5 | Core 0-100 mL | NCCT/DWI-MRI
✅ POSITIVE | mRS 0-3: 36% vs 26%, P=0.02, NNT=10
🔵 ANGEL-ASPECT (2023)
ASPECTS 3-5 OR Core 70-100 mL | CTP/DWI-MRI
✅ POSITIVE | mRS shift: OR 1.37, P=0.004, NNT=8
🟣 SELECT2 (2023)
ASPECTS 3-5 OR Core ≥50 mL | CTP/DWI-MRI
✅ POSITIVE | mRS shift: OR 1.51, P<0.001, NNT=4.7
🟠 TENSION (2023)
ASPECTS ≤5 OR Core ≥70 mL | CTP/DWI-MRI
✅ POSITIVE | mRS shift: OR 1.53, P=0.004
🔴 TESLA (2024) ⚠️ NEGATIVE
ASPECTS 2-5 | Core 0-100 mL | NCCT ONLY
❌ NEGATIVE | UW-mRS: NOT SIGNIFICANT
🩷 LASTE (2024)
ASPECTS ≤5 | Core 0-100 mL | NCCT/DWI-MRI
✅ POSITIVE | mRS median: 4 vs 6, P<0.001

🧠 EVT Large Core Infarction | PICO Review 2026

Author: NPC | AI Assistant: Notchiii